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KMID : 1161420220250090892
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Journal of Medicinal Food
2022 Volume.25 No. 9 p.892 ~ p.901
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Extraction of Pectin from Orange Peel and Study of Its Protective Effect Against Loperamide-Induced Impaired Gastrointestinal Motor Functions and Oxidative Stress in Rats
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Arrari Fatma
Jabri Mohamed-Amine
Hammami Imen
Sebai Hichem
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Abstract
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Pectin is a polysaccharide attached to carbohydrates. These are substances exclusively of plant origin. The aim of the present study is to evaluate the laxative effects of orange peel pectin extract (OPPE) against constipation induced by loperamide (LOP) in rats. Rats were equally divided into six groups and treated daily 1 week as follows: Control, LOP (3?mg/kg, body weight [b.w.], Per Os [p.o.]), LOP+yohimbine (2?mg/kg, b.w., i.p.), and LOP+OPPE (6.25, 12.5, and 25?mg/kg, b.w., p.o.). At the end of the experiment, the effects of OPPE were assessed by fecal parameters (numbers, weight, and water content), gastrointestinal transit, gastric emptying, serum metabolic parameter changes, intestinal and colon mucosa oxidative stress, and the histological examination. The defecation test showed that administration of LOP (3?mg/kg, b.w., p.o.) leads to the production of remarkable constipation. Indeed, the number and water content of stools decreased (25.50 [n/24?h] and 29.86%) significantly (P?
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KEYWORD
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constipation, gastrointestinal motility, LOP, oxidative stress, pectin
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